Active Ingredient: Isotretinoin
Skin biopsies were performed before and after the end of therapy, and the various sections were submitted to specific staining for collagen and elastic fibres. Clinical results of therapy regarding texture, colouring and aspect of the wrinkles were assessed by both physician and patient.
The increase in the amount of collagen fibres was statistically significant with both dosage regimens mean, 37. A pattern pointing toward a decrease in the number of elastic fibres was found mean, 15.
Additionally, there was improvement in the general aspect of the skin, regarding texture, wrinkles depth and skin coloration. The researchers found not imagine what that to be.
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