Active Ingredient: Isotretinoin
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Disease of the sebaceous glands. Dermatology in General Medicine. New York: McGraw-Hill; 1999. Br J Dermatol.
Isotretinoin for acne vulgaris — 10 years later: A safe and successful treatment. The cost-effectiveness of isotretinoin in the treatment of acne.
A meta-analysis of effectiveness literature. S Afr Med J. Washington. C: 1991.
Report of the Consensus Conference on Acne Classification; pp.
Supporting this result, Jackson et al showed improvement in facial erythema within 30 minutes of initial daily application of brimonidine tartrate in Phase III clinical studies.
In two adults with refractory erythema and flushing associated with rosacea, oxymetazoline nasal solution 0.
Significant improvement in facial erythema was seen after only one day of application. The efficacy, safety, and cost-effectiveness of both agents are well demonstrated in a number of well controlled randomized studies.
There are a number of alternative topical non-FDA-approved therapies for patients with rosacea that is refractory to primary topical treatments.