Active Ingredient: Ciprofloxacin
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Your pharmacist can provide more information about ciprofloxacin. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Glutathione reduction in human seminal plasma leads to instability of the midpiece of the spermatozoa, resulting in a motility disorder. Accordingly, its supplementation in infertile men with unilateral varicocele or inflammation of the urogenital tract two conditions in which radical oxygen species or another toxic compound production plays a pathogenetic function leads to a significant improvement of sperm parameters, such as concentration, motility, and morphology.
These effects on spermatozoa can be partially reversed in case of not too severe structural cell membrane damage, a prominent protective role of GSH on the lipid components of the cell membrane.
Hence, glutathione is seldom prescribed for male infertility. NAC is effective in metal chelation and it seems to improve sperm motility and to prevent sperm DNA oxidative damage.
In an animal model, it is able to improve sperm parameters and seminal vesicles weight, previously altered by treatment with As 2 O 3. Furthermore, it significantly improves seminal fluid volume and viscosity and increase sperm motility in humans.
Such findings support the therapeutic use of this compound for the treatment of human infertility.
NAC is commercialized in combination with other antioxidants. Vitamin A Carotenoids are a group of fat-soluble organic compounds found mainly in yellow, red, orange, and pink vegetables.
These retinoids are precursor of vitamin A. Retinal is formed from them in the gastrointestinal tract, before being converted to retinol, the most important component of vitamin A.
Carotenoids are natural antioxidants that protect cell membrane integrity, regulate epithelial cell proliferation, and are involved in the regulation of spermatogenesis.
Moreover, in rats retinoids have various effects on fetal and neonatal Sertoli, germ, and Leydig cell. Carotenoid deficiency in the diet can lead to a reduction in sperm motility.
Studies conducted on bulls have shown that retinol might stabilize sperm acrosomal membrane when oxidative stress increases because of the high temperature.
In humans, lower serum retinol concentration has been correlated to a worse sperm quality.