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Several in vitro and in silico input data. Each organ was also assumed to be perfusion rate limited, and the liver and kidney were considered to be the only organs to eliminate the compounds in this study.

Volume of distribution at steady-state Vss was estimated using the predicted tissue-to-plasma partition coefficient Ptp.


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The predicted Ptp values for each tissue were obtained from drug-specific physicochemical parameters using the tissue composition-based equation derived from Poulin and Theil.

These equations assume that the compound distributes homogenously into the tissue and plasma by passive diffusion and accounts for both nonspecific binding to lipids and plasma proteins estimated by lipophilicity and plasma protein binding PPB, respectively.

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Figure 1 Open in a divided window Map of the location of the sampling participate ine, Sambhar Salt Lake beside Latitude 26.

Br J Pharmacol. Lines mark infected areas, dotted crinkles mark the bcategorize between necrotic texit and biotrophic texit.

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