Active Ingredient: Ciprofloxacin
Tetanus - diphtheria vaccine is recommended for all travelers who have not received a tetanus-diphtheria immunization within the last 10 years. Measles - mumps - rubella vaccine: two doses are recommended if not previously given for all travelers born after 1956, unless blood tests show immunity.
Many adults born after 1956 and before 1970 received only one vaccination against measles, mumps, and rubella as children and should be given a second dose before travel.
MMR vaccine should not be given to pregnant or severely immunocompromised individuals.
Cholera vaccine is not recommended. Cholera is not being reported from Guyana at this time.
Microbiologic methods. Clean-catch, midstream urine samples collected at the baseline pretreatment visit were sent to a central laboratory Pathway Diagnostics, Garden Grove, CA, where the urine was cultured by standard techniques for the identification and quantitative determination of uropathogens.
Uropathogens were identified to the species level. Statistical methods.
The modified intent-to-treat mITT population included all randomized patients who met the enrollment criteria for positive urine culture i. The efficacy population included mITT patients who had microbiological data at the test-of-cure visit.
Patients who used additional antimicrobial agents prior to the test-of-cure visit were excluded from the mITT and efficacy populations for the analysis of microbiological data. Patients who used additional antimicrobial agents were classified as clinical failures if the additional agents were used to treat the uUTI.
Data from all study centers were pooled for analysis.
Among patients in Phase II and III clinical trials, 228 received moxifloxacin concomitantly with other agents that prolong the QTc interval amiodarone, amitriptiline, cisapride clarithromycin, clomipramine, procainamide, quinidine, quinine, sotalol, terfenadine, etc.
One patient had an arrhythmia associated with a prolongation of the QTc interval compared with none of 199 patients who received the comparator agent.
Three of 3780 patients who received moxifloxacin alone had unspecified arrhythmias. In post-marketing surveillance, of about 2 million spontaneous reports there was a single reported case of TdP in an elderly female patient with several risk factors for ventricular arrhythmia hypokalaemia, CAD, digoxin and a pacemaker inserted for a sick sinus syndrome.
Gemifloxacin Of 119 subjects including populations at high risk for QT prolongation receiving a single 320 mg standard therapeutic dose, QTc prolongation was 3.
No QTc prolongation was noted following 14 days of therapy in 40 volunteers treated with doses of 100—1200 mg daily. Key Point: Azithromycin works quite well as an IV antibiotic but is much weaker in oral form.
This is the second time I am making this point because it is very important. It is essential to your recovery that, at a minimum, your treatment address the steps outlined in my Lyme disease treatment guidelines: The Ross Lyme Support Protocol.
Even a year or more into your treatment, these ten steps are essential to resuscitate and support the immune system. Pulse Dosing.
Pulsing herbal antibiotics does not work well, therefore, I do not recommend it here. Clinically, continuous use of herbal antibiotics works best in most situations. The only time I pulse is for two months on and two months off when using regimens to address persister Lyme.
For more information about this see How to Treat Persister Lyme.