Active Ingredient: Ciprofloxacin
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They gave a PCR test for detection. In the current situation of intentional anthrax distribution, doxycycline and ciprofloxacin as the recommended drugs for prophylaxis.
Trovafloxacin is a relatively new quinolone for which these side effects have not been described.
Microbiological and clinical efficacy outcomes. The primary efficacy endpoint was microbiological eradication in the efficacy population at the test-of-cure visit.
Secondary efficacy endpoints included additional microbiological outcomes persistence and new infection at the test-of-cure visit, clinical cure and clinical failure at the test-of-cure visit, microbiological outcomes sustained eradication, persistence, recurrence, and new infection at the late-posttreatment visit, and clinical outcomes sustained cure, relapse, and failure at the late-posttreatment visit.
Clinical cure was defined as the resolution of all clinical signs pyuria and hematuria and symptoms dysuria, frequency, urgency, and suprapubic pain of uUTI and no other antibiotic use.
Clinical failure was persistence or recurrence of any clinical signs or symptoms after completion of therapy.
Relapse was the recurrence of any clinical signs or symptoms following resolution at the test-of-cure visit. Adverse events were recorded throughout the study by direct questioning and observation of patients and from the results of physical examinations and clinical laboratory tests.
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