Active Ingredient: Ciprofloxacin
+ free Cipro pill.
In addition, a higher mutation rate to decreased susceptibility has previously been reported for S. Blister fluid concentrations of antibiotics are considered to be representative of those achieved in some tissues and have been measured for ciprofloxacin by Crump et al.
Exposure to simulated blister fluid concentrations of both doses resulted in the selection of resistant variants of S.
This value was similar, however, for concentrations achieved in serum and blister fluid at each dose level c.
In studies against S.
Exposure to sparfloxacin, on the other hand, yielded less susceptible variants of S. The resistant isolates selected following exposure to ciprofloxacin and sparfloxacin were generally four- to eight-fold less susceptible to ciprofloxacin and trovafloxacin, and two- to four-fold less susceptible to sparfloxacin than the parent culture.
This suggests that efflux did not play a role in the resistance of these isolates.
The greater effect on the potency of ciprofloxacin and trovafloxacin compared with sparfloxacin suggests that these variants contain mutations in grlA or grlB, the genes encoding the ParC and ParE subunits of topoisomerase IV, rather than gyrA or gyrB, which encode the GyrA and GyrB subunits of DNA gyrase.
For ciprofloxacin, this is consistent with the findings of Pan et al.
However, it is not consistent with published genetic studies on sparfloxacin-selected variants, which were found to contain only mutations in GyrA. Acute pyelonephritis is one of the most common serious bacterial infections in young adult women.
Because of the frequency and severity of the infection, physicians must be familiar with approaches to effective management.
This includes making an accurate diagnosis, deciding between inpatient and outpatient management, and selecting an appropriate antimicrobial regimen that is consistent with expert guidelines and local susceptibility data.
Table 4. The study was conducted in full compliance with the principles of GLP.
The MIC 50 values of enrofloxacin against the cultures used in this study had been determined previously in the study of Marshall 1996.
Two isolates of each of five genera obtained from patients before antibiotic therapy were selected.
The mixture was supple-mented with physiological levels of bile salts and pancreatin, then adjusted to pH 7. The results of this study are summarized in Table 5.
The investigator pointed out that the viable counts of all 10 bacterial strains exposed to enrofloxacin in this intestinal model experiment increased during the 18-h incubation period. These results suggest that the concentrations of enrofloxacin tested.
Table 5. These conditions are clinically useful in the treatment of travellers' diarrhoea, therapy for immunocompromised patients, selective decontamination before colorectal surgery, and therapy for burn victims and leukaemia patients.