Active Ingredient: Doxycycline
This combination is also used when treatment of severe malaria with artesunate fails.
In some African hospitals, oral doxycycline is used systematically in combination with intravenous artesunate in the treatment of severe P. Additionally, some severe P. In this review, the potential effects of doxycycline on teeth were re-analysed.
Potential for adverse dental effects Tetracycline compounds have been used since 1953. Doxycycline was developed in 1967.
In the early 1960 s, dental side-effects were associated with the use of tetracycline. In a large study in 520 children, tetracycline was determined to be the probable causative agent of dental defects in 112 cases 21.
However, it was shown in experimental animals that tooth discolouration was more associated with tetracycline than with chlortetracycline or oxytetracycline. Studies using doxycycline in children have reported little or no effect on teeth.
Lochary and co-workers did not find any significant difference in dental staining between 10 children treated with doxycycline and 20 control children without treatment.
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