Active Ingredient: Doxycycline
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From to, the minimum concentrations of cefixime needed to inhibit the growth in vitro of N.
Reports from Europe recently have described patients with uncomplicated gonorrhea infection not cured by treatment with cefixime 400 mg orally 5—8. Each month, the first 25 gonococcal urethral isolates collected from men attending participating STD clinics approximately 6,000 isolates each year were submitted for antimicrobial susceptibility testing.
The minimum inhibitory concentration MIC, the lowest antimicrobial concentration that inhibits visible bacterial growth in the laboratory, is used to assess antimicrobial susceptibility.
Cefixime susceptibilities were not determined during — because cefixime temporarily was unavailable in the United States at that time. During —, 15 0.
Because increasing MICs can predict the emergence of resistance, lower cephalosporin MIC breakpoints were established by GISP for surveillance purposes to provide greater sensitivity in detecting declining gonococcal susceptibility than breakpoints defined by CLSI.
In the West, the percentage increased from 0. Among MSM, the percentage increased from 0. Among 180 isolates collected during — that exhibited elevated cefixime MICs, 139 77.
Ceftriaxone as a single intramuscular injection of 250 mg provides high and sustained bactericidal levels in the blood and is highly efficacious at all anatomic sites of infection for treatment of N.
A 400-mg oral dose of cefixime does not provide bactericidal levels as high, nor as sustained as does an intramuscular 250-mg dose of ceftriaxone, and demonstrates limited efficacy for treatment of pharyngeal gonorrhea 10,11.
Do not start, stop, or change the dosage of any medicines without your doctor's approval. Make sure laboratory personnel and all your doctors know you use this drug.
Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
Canada residents can call a provincial poison control center. Notes Do not share this medication with others.
If this medication is being used to prevent malaria, it is important to understand that it is still possible to get the disease even if you have used this medication.
Avoid being bitten by mosquitoes when trying to prevent malaria.