Active Ingredient: Norfloxacin
As a positive control, the same vector significantly protected against the excitotoxin kainic acid.
This finding supports the view that neurotoxicity induced by 3 AP is likely to have only minimal apoptotic facets. On a broader level, it suggests some limitations in the neuroprotective potential of gene therapy with Bcl-2.
We have previously used herpes simplex virus amplicon vectors to overexpress the rat brain glucose transporter, Glut-1 GT, and have shown it to protect against a variety of necrotic insults both in vitro and in vivo, as well as to buffer neurons from the steps thought to mediate necrotic injury.
It is critical to show the specificity of the effects of any such transgene overexpression, in order to show that protection arises from the transgene delivered, rather than from the vector delivery system itself.
Antibacterial Spectrum of Fosfomycin Trometamol. J Antimicrob Chemother. Patel SS, et al.Cost Accessed from.
Bergan T. Reeves DS. Fosfomycin Trometamol.
Stein GE. Ann Pharmacother. Cost Accessed from. Adverse event rates were similar, as 5. Another comparative trial demonstrated that single-dose fosfomycin tromethamine was comparable to a 5-day course of trimethoprim 200 mg twice daily in eradicating bacteriuria in acute cystitis fosfomycin 83.
Single-dose therapy of uncomplicated UTI offers several advantages over multidose therapy, including better patient compliance and reduced selective pressure for resistant uropathogens.
Overall, published and unpublished data with fosfomycin suggest that it is inferior to first-line agents TMP-SMX, fluoroquinolones currently available for the management of acute uncomplicated UTI.
Although the bacteriologic cure rates, overall clinical success rates, and adverse effect profiles were similar for single-dose fosfomycin tromethamine and 7-day nitrofurantoin, fosfomycin tromethamine is considerably more expensive than nitrofurantoin, as it is not marketed as a generic agent.
In summary, fosfomycin tromethamine should be considered as an alternative treatment option for women with a history of noncompliance with multidose treatment regimens, those with UTI due to resistant pathogens, and those unable to take other oral antimicrobials due to allergy.
References Griebling TL.