Active Ingredient: Ivermectin
Current strategies to combat malaria transmission in South America include diagnosis and treatment with artemisinin-based combination therapy ACT and long-lasting insecticidal nets, supported by indoor-residual spraying of insecticide IRS.
Anopheles aquasalis and Anopheles darlingi are known to be susceptible to P. Anopheles aquasalis is considered the primary vector in coastal areas of Central and South America and has been used as a neotropical anopheline vector for laboratory model to evaluate host-parasite interactions.
Anopheles darlingi is the primary vector in the Amazonian region of South America. The reemergence of attention on transmission blocking strategies for Plasmodium have raised research efforts in attempt to find vaccines, drugs or microorganisms able to disrupt the life cycle of the parasite in the mosquito vector.
In this context, the endectocide ivermectin IVM has arisen as a new promising tool to be added to malaria control programs.
Ivermectin is a safe drug with activity against a wide range of internal and external parasites and it is used widely in both veterinary and human medicine. Ivermectin has a secondary effect on ectoparasites that feed on recently treated individuals, including activity against Anopheles vectors at concentrations present in human blood after standard doses.
Consequently, IVM has emerged as a potential tool for malaria control. Ivermectin MDA provides a unique insecticide dissemination route via mosquito ingestion of the compound through a blood meal rather than physical contact as most insecticides are delivered.
In Anopheles vectors, IVM acts as an agonist of glutamate-gated chloride channels, causing flaccid paralysis and eventual death.
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It revealed that boys were getting an average 29 minutes of moderate to vigorous exercise per day, while girls were getting 18 minutes.
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